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a-ODPA_en active pharmaceutical ingredients active pharmaceutical ingredients（API） alkylhalide allyl bromide alpha-bromo compound antibacterial agent batch synthesis brominating agents bromination bromine bromine compounds contracted production contracted research coupling reactions DBDMH_en electronic material electronics emergency Etak® Fukuyama Godo Shigen gynecological investigational drug halogenoalkanes higher-order compounds synthesized Hiroshima intermediates iodination iodine Japan Aerospace Exploration Agency (JAXA) light-sensitive materials NBS_en new drug ODPA-C_en OLED components organic synthesis p-nitrobenzyl bromide pharmaceutical pharmaceutical intermediates polyimide polyimide monomer semiconductor material semiconductors Sustainable DevelopmentGoals (SDGs) synthesizing