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a-ODPA_en active pharmaceutical ingredients（API） alkylhalide allyl bromide alpha-bromo compound antibacterial antibacterial agent asymmetric final products bromination bromine bromine compounds contracted production contracted research coupling reactions disinfect electronic material electronic materials electronics emergency flavorants Fukuyama Godo Shigen gynecological investigational drug haloalkanes halogenoalkanes hetero halogen higher-order compounds synthesized Hiroshima hygiene intermediates iodination iodine Japan Aerospace Exploration Agency (JAXA) light-sensitive materials new drug ODPA-C_en p-nitrobenzyl bromide pharmaceutical pharmaceutical intermediates polyimide polyimide monomer quaternary ammonium chloride semiconductor material semiconductors synthesizing